A new study in a British medical
journal has stirred a passionate de-
bate among doctors in Europe and
the United States by asserting that
mammograms do not prevent wom-
en from dying of breast cancer or
help them avoid mastectomies.
The question is dividing experts
and women's health advocates,
many of whom acknowledge that
they do not know what to think about
the new report. For more than two
decades, annual mammograms have
been part of life for millions of wom-
en, with the American Cancer Soci-
ety and the National Cancer Institute
urging women to have them.
Experts are still digesting the new
findings, which appeared in the Oct.
20 issue of the journal The Lancet,
and few if any authorities in the.....
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Those studies that found benefits
from mammography were flawed,
say the investigators, Dr. Peter
Gotzsche, director of the Nordic
Cochrane Center in Copenhagen...
.........
For example they criticize a Ney
York study from more than a quar-
ter of a century ago finding that
women who never had a mammo-
gram died of breast cancer at a rate
30 percent higher than those who had
the test. (Of the 30,565 who were
never screened, 196 died over an 18-
year period; of the 30,131 who had
the test, 153 died.)
"The quality of the trials was very
surprising because it is pretty low,"
Dr. Gotzsche said in a telephone in-
terview. "Even if they are judged by
yesterday's standards, the quality is
low. In some cases, we know why
that happened - these trials were
conducted by people who were unfa-
miliar with clinical trial methodolo-
gy. They were run by enthusiastic
clinicians."
The researchers cite with greater
approval a more recent study in
Malmo, Sweden, that compared
21,088 women who had mammo-
grams to 21,195 who served as con-
trols. After nearly nine years, 63
women in the mammogram group
had died of breast cancer, compared
with 66 in the control group - an
insignificant difference. The other
study the researchers approved of,
done in Canada, involved 44,925 wom-
en who had mammograms and
44,910 who did not. There were 120
deaths from breast cancer in the
screened group and 111 among the
women who served as controls.
Nor did mammography lead to
fewer mastectomies, the investiga-
tors say. In the Malmo study, for
example, 424 women in the mam-
mography group and just 339 in the
control group had mastectomies.
One reason may be that doctors ag-
gressively treated some tiny tumors
found in mammograms - tumors
that might never have developed into
cancer or might never have been
noticed in a woman's lifetime.